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The first malignant primary hepatic glomus tumor: A case report
John G Aversa1, Cara Monroe2, Amelia Levi1
1Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
International Journal of Surgery Case Reports
|May 19, 2020
Summary
This report details the first known malignant primary hepatic glomus tumor (GT), a rare liver mass. The case highlights diagnostic challenges and the importance of considering malignant GTs in differential diagnoses for liver lesions.
Area of Science:
- Oncology
- Surgical Pathology
Background:
- Glomus tumors (GTs) are rare neoplasms originating from glomus bodies.
- Primary hepatic GTs have exclusively been reported as benign.
- This study introduces the first documented case of a malignant primary hepatic GT.
Observation:
- A 60-year-old male presented with constitutional symptoms and a large liver mass with significant mass effect.
- Initial biopsies were nondiagnostic, necessitating surgical resection.
- The tumor adhered to major vascular structures, posing surgical complexity.
Findings:
- Histopathologic and immunohistochemical analyses confirmed a malignant GT.
- Next-generation sequencing identified an inactivating TP53 mutation.
- The case underscores the diagnostic challenges in differentiating benign from malignant liver masses.
Implications:
- Malignant hepatic GTs should be included in the differential diagnosis for atypical liver masses.
- Meticulous surgical technique and advanced diagnostics are crucial for management.
- Further research into GT genomics is warranted to improve diagnostic and therapeutic strategies.
