Sobriety and Satiety: Is NAD+ the Answer?
Nady Braidy1, Maria D Villalva1, Sam van Eeden2
1Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney NSW 2052, Australia.
Antioxidants (Basel, Switzerland)
|May 20, 2020
Summary
Nicotinamide adenine dinucleotide (NAD+) plays a key role in cellular health and longevity. Emerging research suggests NAD+ metabolism influences addiction neurobiology, offering potential as an anti-addiction intervention.
Area of Science:
- Biochemistry
- Neuroscience
- Addiction Research
Background:
- Nicotinamide adenine dinucleucleotide (NAD+) is vital for cellular energy, stress defense, and longevity.
- NAD+ metabolism and NAD-dependent enzymes are increasingly linked to addiction neurobiology.
- Current clinical evidence for NAD+ in addiction treatment is limited.
Purpose of the Study:
- To review existing literature on NAD+'s influence on addiction neurobiology.
- To explore the potential of NAD+ as a therapeutic target for addiction.
- To highlight NAD+ as a potential intervention for substance abuse and food addiction.
Main Methods:
- Literature review of studies on NAD+ metabolism and addiction.
- Analysis of NAD-dependent enzymes and signaling pathways in addiction.
- Examination of preclinical and clinical findings related to NAD+ and addictive behaviors.
Main Results:
- NAD+ metabolism components significantly impact neurobiological pathways relevant to addiction.
- Evidence suggests that increasing intracellular NAD+ levels may modulate addictive behaviors.
- NAD+ may help reduce cravings and withdrawal symptoms associated with addiction.
Conclusions:
- NAD+ influences the neurobiology of addiction through various cellular mechanisms.
- Targeting NAD+ metabolism presents a promising avenue for novel anti-addiction therapies.
- Further clinical research is warranted to establish NAD+ efficacy in treating addiction.
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