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The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Tumor-responsive dynamic nanoassemblies for targeted imaging, therapy and microenvironment manipulation.

Liang Ee Low¹, Jiahe Wu¹, Jiyoung Lee¹

¹Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China; Key Laboratory of Biomedical Engineering of the Ministry of Education, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, Zhejiang 310027, China.

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|May 20, 2020

Summary

Dynamic nanoassemblies offer targeted tumor imaging and therapy. This review explores their development, focusing on nano-bio interactions within the tumor microenvironment (TME) for improved cancer treatment strategies.

Keywords:

Controlled delivery Dynamic nanoassembly TME modulation Tumor targeting Tumor therapy

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Area of Science:

Biomedical Engineering
Nanotechnology
Oncology

Background:

Dynamic nanoassemblies show promise for tumor-specific delivery, enhancing imaging and therapeutic efficacy.
Current research often overlooks nano-bio interactions within the tumor microenvironment (TME).
Understanding TME is crucial for designing effective nanoassembly-based cancer therapies.

Purpose of the Study:

To review the development of tumor-responsive nanoassemblies for imaging, therapy, and TME modulation.
To outline tumor biology and TME properties relevant to nanoassembly design.
To discuss strategies for TME modification using dynamic nanoassemblies.

Main Methods:

Literature review of dynamic nanoassemblies in cancer research.
Analysis of tumor biology and TME characteristics.
Synthesis of approaches for TME modulation and therapeutic enhancement.

Main Results:

Nanoassemblies can be designed to respond to TME cues for targeted delivery.
TME modulation strategies using nanoassemblies can enhance antitumor effects.
Dynamic nanoassemblies offer potential for advanced cancer imaging and combination therapies.

Conclusions:

Dynamic nanoassemblies are a promising platform for targeted cancer therapy and imaging.
Further understanding of nano-bio interactions in the TME is essential for optimizing designs.
These strategies may lead to novel combinational cancer therapeutics.