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Infantile subcortical leukohypodensity demonstrated by computed tomography
S Houdou1, S Takashima, K Takeshita
1Division of Child Neurology, Tottori University School of Medicine, Yonago, Japan.
Pediatric Neurology
|May 1, 1988
Summary
Subcortical leukohypodensity (SLD) in infants may be a transient finding, potentially indicating a mild form of leukomalacia. Careful follow-up imaging is recommended for infants with SLD.
Area of Science:
- Neonatal imaging
- Pediatric neurology
- Neuroradiology
Background:
- Subcortical leukohypodensity (SLD) is an imaging finding observed in infants.
- The clinical significance and natural history of SLD require further elucidation.
Purpose of the Study:
- To investigate the incidence, imaging characteristics, and neurodevelopmental outcomes associated with subcortical leukohypodensity in term infants.
Main Methods:
- Retrospective review of computed tomography (CT) scans from 126 term infants aged 1-6 months.
- Analysis of serial CT scans to observe changes in SLD and ventricular morphology.
- Correlation of imaging findings with neurodevelopmental outcomes.
Main Results:
- Subcortical leukohypodensity (SLD) was identified in 2.4% of infants (3 out of 126) aged 1-3 months.
- In follow-up scans after 4 months, SLD resolved, and anterior horn predominant lateral ventricular dilatation appeared.
- One infant with distinct SLD exhibited a poor neurodevelopmental outcome (spastic diplegia).
Conclusions:
- Transient SLD is likely related to subcortical leukomalacia, possibly representing a milder form.
- Careful CT follow-up is warranted for infants diagnosed with SLD in early infancy.