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Association between Serum Vitamin C and the Blood Pressure: A Systematic Review and Meta-Analysis of Observational

Li Ran1, Wenli Zhao2, Xiaodong Tan1

  • 1Department of Occupational and Environmental Health, School of Health Sciences, Wuhan University, Wuhan 430071, China.

Cardiovascular Therapeutics
|May 20, 2020
PubMed

Insights

Individuals with hypertension exhibit lower serum vitamin C levels. This study confirms vitamin C

Area of Science:

  • Cardiovascular Health
  • Nutritional Science
  • Medical Research

Background:

  • Hypertension is a primary risk factor for cardiovascular diseases.
  • Previous research suggests an inverse correlation between vitamin C intake and blood pressure.

Purpose of the Study:

  • To investigate the relationship between serum vitamin C levels and blood pressure.
  • To determine concentration differences and correlation strength between serum vitamin C and blood pressure.

Main Methods:

  • Systematic literature search across multiple databases (PubMed, Cochrane, Web of Science, CNKI, VIP, WANFANG).
  • Inclusion of 18 eligible studies (14 English, 4 Chinese).
  • Data analysis performed using Reviewer Manager 5.3.

Main Results:

  • Hypertensive subjects showed significantly lower serum vitamin C concentrations (mean difference = -15.13 μmol/L, P = 0.001).
  • Serum vitamin C demonstrated a significant inverse association with systolic blood pressure (Fisher's Z = -0.17, P < 0.00001).
  • Serum vitamin C also showed a significant inverse association with diastolic blood pressure (Fisher's Z = -0.15, P < 0.00001).

Conclusions:

  • Individuals diagnosed with hypertension tend to have lower serum vitamin C levels.
  • Vitamin C is inversely associated with both systolic and diastolic blood pressure.
Abstract

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