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Related Experiment Video

Updated: Dec 21, 2025

Author Spotlight: Combined Peripheral Nerve Stimulation and Controllable Pulse Parameter Transcranial Magnetic Stimulation to Probe Sensorimotor Control and Learning

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Sedation Modulates Frontotemporal Predictive Coding Circuits and the Double Surprise Acceleration Effect.

Adrien Witon^1,2, Amirali Shirazibehehsti^1,3, Jennifer Cooke⁴

¹School of Computing, University of Kent, Kent CT2 7NF, UK.

Cerebral Cortex (New York, N.Y. : 1991)

|May 20, 2020

Summary

This summary is machine-generated.

This study reveals how the brain transitions from predictive processing to a global workspace. Sedation selectively disrupts intermediate brain interactions, supporting predictive coding's role in consciousness.

Keywords:

EEG analysis global workspace predictive coding source inversion

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Area of Science:

Cognitive Neuroscience
Neuroimaging
Computational Neuroscience

Background:

Predictive coding (PC) and global workspace (GW) theory are key cognitive neuroscience frameworks.
Understanding the brain's transition from predictive states to global states is crucial.

Purpose of the Study:

To investigate the relationship between predictive coding and global workspace theory.
To elucidate the neural mechanisms underlying the transition from local predictive processing to brain-scale global workspace engagement.

Main Methods:

Source localization of electroencephalography (EEG) responses.
Utilized the local-global task to probe predictive hierarchies and global workspace.
Investigated the effects of propofol sedation on neural processing phases.

Main Results:

Identified three distinct phases of neural processing: sensory, intermediate modulatory, and brain-scale global.
Sensory phase involves auditory regions predicting regularities; global phase involves frontal and parietal regions.
Intermediate phase shows interactions between frontal and temporal regions, selectively reduced by propofol.

Conclusions:

The findings support a phased model of brain processing, integrating predictive coding and global workspace.
Propofol's effect on intermediate phase interactions supports a predictive coding explanation of sedation.
This research offers insights into the neural basis of consciousness and sedation.