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Progress in Photobiomodulation for Bone Fractures: A Narrative Review
Weyland Cheng1, Manye Yao1, Keming Sun1
1Department of Orthopaedics, Children's Hospital Affiliated of Zhengzhou University, Zhengzhou, China.
Photobiomodulation, Photomedicine, and Laser Surgery
|May 20, 2020
Summary
Photobiomodulation (PBM) shows promise for bone fracture healing, with effective results in animal studies. Further research is needed to optimize PBM parameters for human fracture treatment.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Orthopedics
Background:
- Photobiomodulation (PBM) utilizes light to stimulate cellular processes.
- In vitro and animal studies suggest PBM's efficacy in promoting bone regeneration.
- Clinical evidence for PBM in human fracture treatment remains limited.
Purpose of the Study:
- To review current concepts and future directions for PBM implementation in fracture treatment.
- To synthesize findings from existing literature on PBM for bone healing.
- To identify research gaps in the clinical application of PBM for fractures.
Main Methods:
- A narrative review of studies published between 2000 and 2019.
- Inclusion of studies utilizing animal or human fracture models.
- Exclusion of studies not involving complete fractures or employing additional interventions.
Main Results:
- Analysis included ten animal studies (rats, rabbits) and four clinical trials on complete fractures.
- Animal studies demonstrated positive outcomes for PBM in bone healing.
- Limited clinical data currently exists for PBM in human fracture treatment.
Conclusions:
- PBM exhibits potential for enhancing bone fracture healing.
- Extensive research is required to optimize PBM parameters (dosage, wavelength, frequency, etc.) for human clinical application.
- Further clinical trials are necessary to validate PBM's effectiveness in treating human fractures.
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