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Related Concept Videos

Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

485
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
485
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

501
Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
501

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Related Experiment Video

Updated: Dec 21, 2025

Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
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Supervised pulmonary hypertension exercise rehabilitation (SPHERe): study protocol for a multi-centre randomised

Gordon McGregor1,2,3, Julie Bruce4, Stuart Ennis5,4

  • 1Department of Cardiopulmonary Rehabilitation, Centre for Exercise & Health, University Hospitals Coventry & Warwickshire NHS Trust, Coventry, UK. gordon.mcgregor@warwick.ac.uk.

BMC Pulmonary Medicine
|May 21, 2020
PubMed
Summary

This study evaluates supervised exercise rehabilitation for pulmonary hypertension (PH) patients in the UK NHS. Results will determine if this intervention should be standard care for all PH groups.

Keywords:
Cardiac rehabilitationComplex interventionPulmonary hypertensionPulmonary rehabilitationRandomised controlled trial

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Area of Science:

  • Cardiology
  • Pulmonology
  • Rehabilitation Medicine

Background:

  • Supervised cardio-pulmonary rehabilitation shows promise for specific pulmonary hypertension (PH) groups (1 and 4) as inpatients.
  • Effectiveness in common PH groups (2, 3, 5), UK outpatient settings, and long-term outcomes remains unevaluated.
  • This study addresses the need for evidence in diverse PH populations and community-based settings.

Purpose of the Study:

  • To assess the clinical and cost-effectiveness of a supervised exercise rehabilitation program for individuals with pulmonary hypertension (PH).
  • To compare the intervention against best practice usual care in a UK National Health Service (NHS) outpatient setting.
  • To provide evidence for the routine implementation of supervised exercise rehabilitation for all PH groups.

Main Methods:

  • A multi-centre, pragmatic, two-arm randomised controlled trial (RCT) involving 352 adults with PH (WHO functional class II-IV).
  • Participants randomized to the Supervised Pulmonary Hypertension Exercise Rehabilitation (SPHERe) intervention (8-week supervised exercise, psychosocial support) or usual care.
  • Primary outcome: Incremental Shuttle Walk Test at 4 months; secondary outcomes include HRQoL, clinical worsening, and healthcare use. Embedded process evaluation with interviews.

Main Results:

  • Primary outcome data (Incremental Shuttle Walk Test at 4 months) is pending.
  • Secondary outcome data (HRQoL, time to clinical worsening, healthcare use) is pending.
  • Process evaluation data will explore participant and practitioner experiences.

Conclusions:

  • The SPHERe study is the first multi-centre RCT in the UK NHS to evaluate supervised exercise rehabilitation for all PH groups.
  • Results will inform clinical practice and commissioning decisions regarding the routine provision of exercise rehabilitation for PH patients.
  • The study aims to establish the effectiveness and cost-effectiveness of the SPHERe intervention.