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Updated: Dec 21, 2025

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
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Multivessel vs. culprit-lesion only percutaneous coronary intervention in ST-elevation myocardial infarction

Hans-Josef Feistritzer1, Alexander Jobs2, Steffen Desch2

  • 1Department of Internal Medicine/Cardiology, Heart Center Leipzig at University of Leipzig, Strümpellstr. 39, 04289, Leipzig, Germany. Hans-Josef.Feistritzer@medizin.uni-leipzig.de.

Herz
|May 21, 2020
PubMed

Insights

Complete revascularization in ST-elevation myocardial infarction (STEMI) patients reduces cardiovascular death and heart attacks. This review examines evidence for optimal treatment of non-infarct arteries in STEMI care.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Clinical Trials

Background:

  • The optimal management of non-infarct-related coronary arteries in ST-elevation myocardial infarction (STEMI) patients remains a long-standing debate.
  • Previous trials suggested benefits of multivessel percutaneous coronary intervention (PCI) mainly by reducing revascularization rates.

Purpose of the Study:

  • To review current evidence on revascularization strategies for patients with STEMI.
  • To evaluate the impact of complete revascularization versus culprit-lesion-only PCI.

Main Methods:

  • Systematic review of randomized controlled trials and relevant clinical studies.
  • Analysis of data from recent large-scale trials like the COMPLETE trial.

Main Results:

  • The COMPLETE trial demonstrated a significant reduction in the composite endpoint of cardiovascular mortality and myocardial infarction with complete revascularization.
  • Earlier trials indicated benefits of multivessel PCI, primarily through decreased need for repeat procedures.

Conclusions:

  • Complete revascularization appears to be a beneficial strategy in STEMI patients, reducing major adverse cardiovascular events.
  • Further evidence supports a comprehensive approach to managing all significant coronary lesions in STEMI.

Keywords:
Multivessel coronary artery diseasePrognosisRandomized controlled trialsRevascularization strategySTEMI

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