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Related Concept Videos

Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

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Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
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Applications of Molecular Taxonomy01:20

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Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: Dec 21, 2025

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
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[Molecular tumor diagnostics-current methods, examples of application and future].

B Sobottka1, A Weber2

  • 1Institut für Pathologie und Molekularpathologie, Universitätsspital Zürich, Universität Zürich, Schmelzbergstraße 12, 8091, Zürich, Schweiz.

Der Pathologe
|May 21, 2020
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Summary

Molecular tumor diagnostics advances rapidly with new technologies like liquid biopsy and immune oncology. Interdisciplinary cooperation is key for optimal patient care in modern cancer diagnostics.

Keywords:
BioinformaticsHigh-throughput sequencingPathology, molecularPersonalized medicinePredictive molecular testing

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Area of Science:

  • Oncology
  • Molecular Pathology
  • Bioinformatics

Background:

  • High-throughput sequencing and bioinformatics are driving rapid advancements in molecular tumor diagnostics.
  • Novel therapeutic strategies, particularly in immune oncology, are emerging alongside diagnostic progress.
  • Molecular stratification and identification of key genetic alterations (e.g., NTRK fusions) are crucial for cancer management.

Purpose of the Study:

  • To highlight the evolving landscape of molecular tumor diagnostics.
  • To emphasize the role of molecular pathology in diagnostic, predictive, and prognostic assessments.
  • To underscore the importance of interdisciplinary collaboration for optimal cancer patient care.

Main Methods:

  • Review of technological advances in high-throughput sequencing and bioinformatics.
  • Discussion of emerging therapeutic approaches, including immune oncology.
  • Exploration of novel diagnostic strategies like liquid biopsy and tumor-agnostic approaches.

Main Results:

  • Molecular stratification of tumors (e.g., colorectal carcinoma) provides diagnostic, predictive, and prognostic information.
  • Identification of specific molecular changes, such as NTRK fusions, impacts treatment decisions.
  • Liquid biopsy and tumor-agnostic strategies represent promising developments in cancer diagnostics.

Conclusions:

  • Effective interdisciplinary cooperation among oncology, bioinformatics, and molecular pathology is essential.
  • Modern oncological diagnostics rely on state-of-the-art knowledge and integrated approaches.
  • Optimizing cancer patient care necessitates a strong foundation in molecular diagnostics and collaborative efforts.