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Updated: Dec 21, 2025
The Insect Galleria mellonella as a Powerful Infection Model to Investigate Bacterial Pathogenesis
Published on: December 11, 2012
The Use of Galleria mellonella (Wax Moth) as an Infection Model for Group A Streptococcus
Catherine Jia-Yun Tsai1, Jacelyn M S Loh2, Thomas Proft3
1Department of Molecular Medicine and Pathology, School of Medical Sciences and Maurice Wilkins Centre for Biomolecular Discovery, The University of Auckland, Auckland, New Zealand. j.tsai@auckland.ac.nz.
Abstract:
Recently, the use of Galleria mellonella larvae as a nonmammalian model to simulate bacterial infectious diseases has shown to be a rapid, simple, and cost-effective alternative. The insect's innate immune response is remarkably similar to that of the vertebrates, and consists of both the cellular and the humoral immune response. Here, we provide a protocol for using G. mellonella larvae to study virulence of GAS, including the use of a health score system for quantitative analysis and the methods for assessing post-infection bacterial burden in vivo.
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