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Continuous "Snowing" Thermotherapeutic Graphene.
Yangyong Sun1,2, Zengzhen Chen3, Huiping Gong2
1Center for Nanochemistry, Beijing Science and Engineering Center for Nanocarbons, Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.
Advanced Materials (Deerfield Beach, Fla.)
|May 21, 2020
Summary
Researchers developed a novel "pulse-etched" microwave-induced "snowing" (PEMIS) process for scalable graphene production. This high-quality graphene shows promise for microwave thermal therapy (MTT), achieving an 86.7% tumor ablation rate.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Scalable, high-quality graphene production remains a significant challenge.
- Graphene's unique properties offer potential for advanced therapeutic applications.
Purpose of the Study:
- To develop a continuous and scalable method for producing high-purity graphene.
- To investigate the potential of this graphene in microwave thermal therapy (MTT).
Main Methods:
- A novel
- pulse-etched
- microwave-induced
- snowing
- (PEMIS) process was employed for gas-phase graphene synthesis.
- Characterization of graphene properties including size, purity, and oxygen content.
- Evaluation of graphene-based system for microwave thermal therapy in a preclinical model.
Main Results:
- The PEMIS process yielded high-quality, high-purity graphene with small size (≈180 nm) and low oxygen content.
- Graphene exhibited efficient gas-solid conversion (≈10.46%) and excellent microwave absorption.
- The graphene-based system demonstrated a high tumor ablation rate of ≈86.7% in microwave thermal therapy.
Conclusions:
- The PEMIS process offers a scalable route to high-quality graphene.
- This biocompatible graphene shows significant potential as a sensitizer for microwave thermal therapy.
- The developed graphene is suitable for novel biomedical applications, particularly in cancer treatment.
