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Prevalence of Vitamin B12 Deficiency in West Syndrome: A Retrospective Chart Review

Manjeet Singh1, Mohit Bansal1, Jaya S Kaushik1

  • 1Department of Pediatrics, Pt. Bhagwat Dayal Sharma, Post Graduate Institute of Medical Sciences (PGIMS), Rohtak, Haryana, India.

Journal of Pediatric Neurosciences
|May 22, 2020
PubMed

Insights

Vitamin B12 deficiency was found in 7.7% of children with West syndrome. Supplementation did not reduce spasm frequency in deficient patients, indicating limited benefit for this condition.

Area of Science:

  • Pediatric Neurology
  • Nutritional Neuroscience

Background:

  • West syndrome is a severe form of epilepsy in infants.
  • Vitamin B12 is crucial for neurological development and function.

Purpose of the Study:

  • To assess vitamin B12 status in children with West syndrome.
  • To evaluate the efficacy of vitamin B12 supplementation in deficient cases.

Main Methods:

  • Retrospective review of hospital records for children with West syndrome.
  • Serum vitamin B12 levels assessed during treatment.
  • Clinical response to vitamin B12 supplementation documented.

Main Results:

  • Vitamin B12 deficiency (levels < 203 pg/mL) identified in 7.7% of 26 children.
  • Common etiologies included cryptogenic (46.2%) and perinatal asphyxia (38.5%).
  • Neither deficient child showed reduced spasm frequency after vitamin B12 supplementation.

Conclusions:

  • A small percentage of children with West syndrome exhibit vitamin B12 deficiency.
  • Vitamin B12 supplementation showed no significant clinical benefit in reducing spasms in this cohort.
Abstract

Keywords:
Epilepsyinfantile spasmsmicronutrientsvitamin B12 deficiency

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