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Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

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Related Experiment Video

Updated: Dec 21, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

Plague During Pregnancy: A Systematic Review.

Shannon Fleck-Derderian^1,2, Christina A Nelson¹, Katharine M Cooley³

¹Bacterial Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America

|May 22, 2020

Summary

Plague during pregnancy poses significant risks to both mother and fetus. Prompt antimicrobial treatment is crucial for survival, though pregnancy loss remains a high risk. Maternal-fetal transmission of Yersinia pestis is possible.

Keywords:

Yersinia pestis fetal plague pregnancy

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Human Placental and Decidual Organ Cultures to Study Infections at the Maternal-fetal Interface

Published on: July 21, 2016

Area of Science:

Infectious Diseases
Maternal-Fetal Medicine
Public Health

Background:

Yersinia pestis (plague) is a global threat and bioterrorism agent.
Limited data exists on plague's impact on pregnancy outcomes.
Understanding maternal, fetal, and neonatal risks is critical.

Purpose of the Study:

To review and synthesize existing literature on plague during pregnancy.
To assess maternal and fetal outcomes associated with Yersinia pestis infection in pregnant individuals.

Main Methods:

Comprehensive literature search across 12 databases.
Inclusion of articles reporting plague in pregnancy with maternal or fetal outcomes.
Consultation with plague experts.

Main Results:

160 cases of plague in pregnant women identified from 59 articles.
Maternal mortality was 29% and fetal fatality 62% with antimicrobial treatment.
Untreated cases showed higher mortality: 67% maternal, 74% fetal.
Evidence of Yersinia pestis transmission to fetus/neonate in 5 cases.

Conclusions:

Untreated plague in pregnancy leads to high maternal and fetal mortality.
Antimicrobial treatment improves maternal survival but pregnancy loss risk persists.
Maternal-fetal transmission of Yersinia pestis is possible, especially without treatment.
Urgent antimicrobial treatment or prophylaxis for pregnant women with suspected plague is essential.