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Updated: Dec 20, 2025

Modeling Human Cerebellar Development In Vitro in 2D Structure
Published on: September 16, 2022
Oxygen Sensing Comes to the Development of the Cerebellum
1Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada.
Abstract:
In this issue of Neuron, Kullmann et al. (2020) demonstrate that the hypoxic state of the developing cerebellum stimulates Hif1a expression to maintain cell proliferation until vascularization creates normoxic conditions, activating Pard polarity signaling complex genes and stimulating cells to cease proliferation and begin migration.
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