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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
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Diabetes and metabolic syndrome as risk factors for COVID-19

Marko Marhl1, Vladimir Grubelnik2, Marša Magdič3

  • 1Faculty of Medicine, University of Maribor, SI-2000, Maribor, Slovenia; Faculty of Natural Sciences and Mathematics, University of Maribor, SI-2000, Maribor, Slovenia; Faculty of Education, University of Maribor, SI-2000, Maribor, Slovenia.

Diabetes & Metabolic Syndrome
|May 22, 2020
PubMed

Insights

Patients with diabetes face higher Coronavirus disease 2019 (COVID-19) risks due to physiological factors. Key biomarkers like hypertension and inflammation predict severe COVID-19 outcomes in diabetic individuals.

Area of Science:

  • Endocrinology
  • Virology
  • Immunology

Background:

  • Clinical observations indicate increased Coronavirus disease 2019 (COVID-19) severity in patients with diabetes.
  • Investigating the physiological underpinnings of this observed link is crucial for understanding disease progression.

Purpose of the Study:

  • To explore the physiological pathways connecting diabetes and COVID-19 severity.
  • To identify biomarkers predicting adverse outcomes in diabetic patients with COVID-19.

Main Methods:

  • Publication mining of PubMed data from 2000-2020 to identify common research themes.
  • Knowledge graph extraction to map interconnections between diabetes and COVID-19.

Main Results:

  • Three pathophysiological pathways identified: Angiotensin-converting enzyme 2 dysregulation, liver dysfunction, and chronic systemic inflammation.
  • Biomarkers predicting higher risk include hypertension, elevated alanine aminotransferase, high interleukin-6, and low lymphocyte count.

Conclusions:

  • Identified biomarkers can aid clinical risk assessment for COVID-19 in diabetic and prediabetic patients.
  • Checking medical history for chronic biomarker dysregulation is recommended for newly infected individuals.
Abstract

Keywords:
ACE2HypertensionInflammationLiver dysfunctionSARS-Coronavirus-2

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