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Biochemical Measurement of Neonatal Hypoxia
Published on: August 24, 2011
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Thromboelastometry Variables in Neonates with Perinatal Hypoxia.
Aikaterini Konstantinidi1, Rozeta Sokou1, Andreas G Tsantes2
1Neonatal Intensive Care Unit, Nikaia General Hospital "Aghios Panteleimon," Piraeus, Greece.
Seminars in Thrombosis and Hemostasis
|May 22, 2020
Summary
Perinatal hypoxia increases coagulation disorder risk in newborns. Thromboelastometry (TEM) shows hypoxic neonates have impaired blood clotting, suggesting TEM
Area of Science:
- Neonatal Medicine
- Hematology
- Perinatal Research
Background:
- Perinatal hypoxia elevates coagulation disorder risk in neonates.
- This is due to hypoxemia, acidemia, and compromised organ function affecting clotting factors.
- Thromboelastometry (TEM) offers a method to assess coagulation dynamics.
Purpose of the Study:
- To evaluate the hemostatic profile of neonates experiencing perinatal hypoxia.
- To utilize the standard extrinsically activated TEM (ex-TEM) assay for this assessment.
- To compare coagulation status between hypoxic neonates and healthy controls.
Main Methods:
- Conducted an ex-TEM assay on 164 hospitalized neonates with perinatal asphyxia/fetal distress and 273 healthy controls.
- Calculated the Score for Neonatal Acute Physiology Perinatal Extension (SNAPPE).
- Recorded clinical findings and laboratory results for all participants.
Main Results:
- Hypoxic neonates exhibited prolonged clotting time (CT) and clot formation time (CFT).
- Reduced amplitude at 10 minutes (A10) and alpha-angle were observed in hypoxic neonates.
- Asphyxiated neonates showed more pronounced clotting abnormalities compared to those with fetal distress.
Conclusions:
- Neonates with perinatal hypoxia display a hypocoagulable ex-TEM profile.
- TEM may aid in the early detection of coagulation abnormalities in perinatal hypoxia.
- This highlights TEM's potential role in managing neonatal coagulation issues.
