Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomics02:02

Genomics

39.4K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
39.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evolution and Expression Divergence of the CYP78A Subfamily Genes in Soybean.

Genes·2018
Same author

Protein-rich extract of <i>Musca domestica</i> larvae alleviated metabolic disorder in STZ-induced type 2 diabetic rat model via hepatoprotective and pancreatic β-cell protective activities.

Journal of biosciences·2018
Same author

Housefly (Musca domestica) larvae powder, preventing oxidative stress injury via regulation of UCP4 and CyclinD1 and modulation of JNK and P38 signaling in APP/PS1 mice.

Food & function·2018
Same author

Fabrication of a Perylene Tetracarboxylic Diimide-Graphitic Carbon Nitride Heterojunction Photocatalyst for Efficient Degradation of Aqueous Organic Pollutants.

ACS applied materials & interfaces·2018
Same author

Dosage imbalance of B- and C-class genes causes petaloid-stamen relating to F<sub>1</sub> hybrid variation.

BMC plant biology·2018
Same author

Fiber2 and hexon genes are closely associated with the virulence of the emerging and highly pathogenic fowl adenovirus 4.

Emerging microbes & infections·2018

Related Experiment Video

Updated: Dec 20, 2025

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.9K

Multitissue Multiomics Systems Biology to Dissect Complex Diseases.

Xia Yang1

  • 1Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA.

Trends in Molecular Medicine
|May 23, 2020
PubMed
Summary
This summary is machine-generated.

Complex diseases require multitissue multiomics systems biology to understand gene-environment interactions. This approach aids in uncovering molecular networks for network-based systems medicine.

Keywords:
complex diseasesgene-by-environment interactionsmultiomicsmultitissuenetworkssystems biology

More Related Videos

Author Spotlight: Advancing Alzheimer's Research &#8211; Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.6K
The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
10:05

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

Published on: April 28, 2015

29.5K

Related Experiment Videos

Last Updated: Dec 20, 2025

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.9K
Author Spotlight: Advancing Alzheimer's Research &#8211; Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.6K
The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
10:05

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

Published on: April 28, 2015

29.5K

Area of Science:

  • Genomics
  • Systems Biology
  • Computational Biology

Background:

  • Complex diseases involve genetic and environmental factors, often following polygenic or omnigenic models.
  • Traditional research methods struggle with the multidimensional complexity of these diseases.
  • Multitissue multiomics systems biology offers a comprehensive approach to study these complexities.

Purpose of the Study:

  • To discuss the concepts, benefits, and current state of multitissue multiomics systems biology.
  • To highlight the challenges and limitations within the field.
  • To propose future directions for network-based systems medicine.

Main Methods:

  • Review and synthesis of current knowledge in multitissue multiomics systems biology.
  • Discussion of systems biology's role in elucidating gene-by-environment interactions.
  • Exploration of network-based approaches for disease research.

Main Results:

  • Systems biology effectively elucidates within- and cross-tissue molecular networks.
  • This approach provides novel insights into complex disease pathophysiology.
  • The field has demonstrated significant power in hypothesis generation.

Conclusions:

  • Multitissue multiomics systems biology is crucial for understanding complex diseases.
  • Addressing current challenges is essential for advancing network-based systems medicine.
  • Future research should focus on integrating multiomics data for a holistic understanding of disease.