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Therapeutic aspects of AMPK in breast cancer: Progress, challenges, and future directions

Lavanya Ponnusamy1, Sathan Raj Natarajan1, Karthik Thangaraj1

  • 1Cell Signaling and Cancer Biology Laboratory, Department of Biochemistry, Guindy Campus, University of Madras, Chennai 600025, India.

Biochimica Et Biophysica Acta. Reviews on Cancer
|May 23, 2020
PubMed

Insights

AMP-activated kinase (AMPK) acts as a tumor suppressor in breast cancer. Activating AMPK pathways and developing AMPK activators show promise for effective breast cancer treatment and opposing tumor progression.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Breast cancer is a prevalent global neoplasm in women.
  • Molecular mechanisms underlying breast cancer development are under intense investigation.
  • AMP-activated kinase (AMPK), a cellular energy sensor, is vital for energy homeostasis.

Purpose of the Study:

  • To review recent advances in understanding the tumor suppressor role of AMPK pathways in breast cancer.
  • To discuss the development and molecular mechanisms of AMPK activators for breast cancer therapy.

Main Methods:

  • Literature review of recent research on AMPK pathways in breast cancer.
  • Analysis of molecular mechanisms involving AMPK phosphorylation and downstream signaling.
  • Examination of studies on AMPK activators and their therapeutic potential.

Main Results:

  • Downregulation of AMPK activity is linked to breast tumorigenesis promotion.
  • AMPK activation demonstrates an inhibitory effect on tumor progression.
  • AMPK activators are emerging as a potential therapeutic strategy.

Conclusions:

  • AMPK functions as a critical tumor suppressor in breast cancer.
  • Targeting AMPK pathways and utilizing AMPK activators represent a promising avenue for breast cancer treatment.
Keywords:
AMPKAMPK activatorBreast cancerNatural compoundsSynthetic compounds

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