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Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells

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Curcumin and neurological diseases.

Raffaella Adami¹, Daniele Bottai¹

¹Department of Health Sciences, University of Milan, Milan, Italy.

Nutritional Neuroscience

|May 23, 2020

Summary

Curcumin, a compound known for thousands of years, shows promise in treating neurological diseases. Research is exploring its mechanisms and bioavailability for therapeutic use.

Keywords:

Alzheimer’s disease Curcumin Parkinson’s disease amyotrophic lateral sclerosis epilepsy multiple sclerosis spinal cord injury spinal muscular atrophy

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Area of Science:

Natural Product Chemistry
Neuroscience
Pharmacology

Background:

Curcumin has a long history of use in Eastern medicine for various ailments.
It is recognized for its anti-inflammatory properties and potential to combat diseases like cancer and diabetes.
Emerging research highlights curcumin's potential therapeutic effects on neurological disorders.

Purpose of the Study:

To review the historical isolation and characterization of curcumin.
To explore curcumin's role in treating a range of neurological diseases.
To summarize clinical trials and discuss bioavailability enhancement strategies.

Main Methods:

Literature review of studies on curcumin's isolation and properties.
Analysis of research on curcumin's cellular and molecular mechanisms in neurological diseases.
Compilation of data from clinical trials involving curcumin.

Main Results:

Curcumin's historical context and chemical characterization are detailed.
Its therapeutic potential in neurological conditions like Alzheimer's and Parkinson's is presented.
Clinical trial outcomes and methods to improve curcumin's bioavailability are discussed.

Conclusions:

Curcumin demonstrates significant potential as a therapeutic agent for neurological diseases.
Understanding its molecular mechanisms is crucial for effective treatment.
Improving curcumin's bioavailability is key to maximizing its clinical efficacy.