Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Narcolepsy01:07

Narcolepsy

377
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
377
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

2.6K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
2.6K
Human Genetics01:28

Human Genetics

1.3K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.3K
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.4K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.4K
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

889
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
889
Incomplete Dominance01:43

Incomplete Dominance

29.4K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
29.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rare Coding Variants Reveal Distinct Genetic Architectures Across Multidimensional Sleep Phenotypes.

medRxiv : the preprint server for health sciences·2026
Same author

Genetic architecture of 67 oral diseases and their links to systemic diseases.

HGG advances·2026
Same author

Genetic variants affect diurnal glucose levels throughout the day.

Nature communications·2026
Same author

Meta-analysis of Cannabis Use Identifies Shared Genetic Loci with Sleep and Circadian Rhythms.

medRxiv : the preprint server for health sciences·2026
Same author

Genetic variation near ROBO1 is associated with craniofacial microsomia and related phenotypes in the Finnish population.

Human molecular genetics·2026
Same author

Genome-wide association meta-analyses over one million individuals identify 54 loci associated with urinary incontinence and its subtypes.

medRxiv : the preprint server for health sciences·2026

Related Experiment Video

Updated: Dec 20, 2025

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

1.2K

Narcolepsy type 1: what have we learned from genetics?

Hanna M Ollila1,2,3,4

  • 1Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.

Sleep
|May 23, 2020
PubMed
Summary
This summary is machine-generated.

Type-1 narcolepsy involves hypocretin loss and suggests an autoimmune origin, not psychiatric. This review explores genetic factors and their immune, genetic, and epidemiological links in narcolepsy subtypes.

Keywords:
autoimmunecomorbidityepidemiologygeneticsnarcolepsypsychiatric

More Related Videos

Noninvasive, High-throughput Determination of Sleep Duration in Rodents
07:33

Noninvasive, High-throughput Determination of Sleep Duration in Rodents

Published on: April 18, 2018

8.1K
Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice
08:58

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice

Published on: June 19, 2019

10.3K

Related Experiment Videos

Last Updated: Dec 20, 2025

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons
08:04

Identification and Classification of Position-specific GABAA Receptor Subunit Missense Variants for Their Role In Hippocampal Pyramidal Neurons

Published on: June 6, 2025

1.2K
Noninvasive, High-throughput Determination of Sleep Duration in Rodents
07:33

Noninvasive, High-throughput Determination of Sleep Duration in Rodents

Published on: April 18, 2018

8.1K
Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice
08:58

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice

Published on: June 19, 2019

10.3K

Area of Science:

  • Neurology
  • Immunology
  • Genetics

Background:

  • Type-1 narcolepsy is a severe neurological disorder characterized by hypocretin neurotransmitter loss.
  • Genetic analysis indicates an autoimmune etiology for type-1 narcolepsy.
  • Other narcolepsy and hypersomnia subtypes remain less understood.

Purpose of the Study:

  • To review recent advancements in narcolepsy research.
  • To elucidate the interplay of genetic, immune, and epidemiological factors in narcolepsy risk.
  • To provide a comprehensive understanding of narcolepsy subtypes.

Main Methods:

  • Literature review of recent breakthroughs in narcolepsy.
  • Analysis of genetic, immune, and epidemiological data.
  • Synthesis of current understanding of narcolepsy subtypes.

Main Results:

  • Genetic factors play a significant role in narcolepsy.
  • Autoimmune processes are implicated in type-1 narcolepsy.
  • Interplay between genetic, immune, and environmental factors influences narcolepsy risk.

Conclusions:

  • Understanding the genetic and immune basis of narcolepsy is crucial.
  • Further research is needed for less-understood narcolepsy subtypes.
  • A comprehensive approach is required to address narcolepsy etiology and risk.