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Updated: Dec 20, 2025

Simple Continuous Glucose Monitoring in Freely Moving Mice
Published on: February 24, 2023
Modeling continuous glucose monitoring (CGM) data during sleep
Irina Gaynanova1, Naresh Punjabi2, Ciprian Crainiceanu3
1Department of Statistics, Texas A&M University, MS 3143, College Station, TX, 77843, USA.
Abstract:
We introduce a multilevel functional Beta model to quantify the blood glucose levels measured by continuous glucose monitors for multiple days in study participants with type 2 diabetes mellitus. The model estimates the subject-specific marginal quantiles, quantifies the within- and between-subject variability, and produces interpretable parameters of blood glucose dynamics as a function of time from the actigraphy-estimated sleep onset. Results are validated via simulations and by studying the association between the estimated model parameters and hemoglobin A1c, the gold standard for assessing glucose control in diabetes.
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