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Activating Autophagy by Aerobic Exercise in Mice
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Activating Autophagy by Aerobic Exercise in Mice

Published on: February 3, 2017

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Exercise-mediated regulation of autophagy in the cardiovascular system

Lijun Wang1, Jiaqi Wang1, Dragos Cretoiu2

  • 1Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai 200444, China.

Journal of Sport and Health Science
|May 24, 2020
PubMed

Insights

Exercise training normalizes cellular degradation (autophagy) in the cardiovascular system. This process helps prevent and treat cardiovascular diseases by restoring proper cell function and delaying disease progression.

Area of Science:

  • Cell Biology
  • Cardiovascular Science
  • Exercise Physiology

Background:

  • Cardiovascular disease (CVD) is a primary global health concern.
  • Autophagy, a cellular degradation process, is vital for cardiovascular homeostasis.
  • Dysregulated autophagy (either excessive or insufficient) contributes to CVD development.

Purpose of the Study:

  • To review the role of autophagy in cardiovascular health and disease.
  • To explore the bidirectional regulation of autophagy by exercise training.
  • To discuss exercise-mediated beneficial effects on the cardiovascular system via autophagy.

Main Methods:

  • Literature review of autophagy mechanisms.
  • Analysis of signaling pathways involved in exercise-induced autophagy.
  • Examination of studies on exercise and cardiovascular outcomes related to autophagy.

Main Results:

  • Autophagy plays a critical role in maintaining cardiovascular function.
  • Exercise training bidirectionally regulates autophagy, correcting both insufficient and excessive states.
  • Exercise interventions can delay the progression of cardiovascular diseases by modulating autophagy.

Conclusions:

  • Exercise training is a potent modulator of autophagy in the cardiovascular system.
  • Restoring normal autophagy through exercise offers a therapeutic strategy for cardiovascular diseases.
  • Understanding exercise-mediated autophagy regulation can inform prevention of various autophagy-related diseases.

Keywords:
AutophagyCardiovascular diseasesExercise

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