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Updated: Apr 21, 2026

Isolation and Identification of Extravascular Immune Cells of the Heart

Isolation and Identification of Extravascular Immune Cells of the Heart

Published on: August 23, 2018

Optimized Cardiac Health by Exercise: Cardiomyocytes and Immune Microenvironment.

Shuqin Liu¹, Meiyu Hu¹, Xinpeng Li¹

¹Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), School of Life Sciences, Shanghai University, Shanghai 200444, China.

Physiology (Bethesda, Md.)

|April 20, 2026

Summary

This summary is machine-generated.

Regular exercise protects heart health by regulating heart cells and the immune system. Understanding these effects can lead to new treatments for heart disease and prevent exercise-related heart damage.

Keywords:

Cardiac Health Cardiomyocytes Exercise Immune Cells Immune Microenvironment Lymphangiogenesis

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Isolation of Functional Cardiac Immune Cells

Isolation of Functional Cardiac Immune Cells

Published on: December 5, 2011

Area of Science:

Cardiology
Immunology
Exercise Physiology

Background:

Exercise is a cost-effective, non-pharmacological method for cardiovascular health.
Exercise influences cardiomyocytes, non-cardiomyocytes, and immune cells in the heart.
The cardiac immune microenvironment plays a crucial role in heart function and disease.

Purpose of the Study:

To review current knowledge on how exercise protects the heart.
To elucidate the regulation of cardiomyocytes and the cardiac immune microenvironment by exercise.
To explore exercise-mimetics for heart disease treatment.

Main Methods:

Literature review of exercise's effects on cardiac cells and immune microenvironment.
Analysis of immune cell infiltration, plasticity, and activation.
Investigation of lymphatic vessel roles and lymphangiogenesis.
Discussion of multi-omics approaches and therapeutic strategies.

Main Results:

Exercise modulates immune cell behavior (infiltration, phenotype, activation) within the heart.
Lymphatic vessels are involved in immune cell trafficking and are affected by exercise.
Multi-omics studies reveal exercise-induced cardiac adaptations.
Excessive exercise carries cardiotoxicity risks.

Conclusions:

Exercise profoundly impacts cardiac cells and the immune microenvironment.
Targeting the cardiac immune microenvironment offers therapeutic potential for heart disease.
Further research can optimize exercise interventions and develop exercise-mimetics.