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Updated: Dec 20, 2025

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Investigating the Link between Psoriasis and Cardiovascular Disease: Current Evidence, Therapeutic Implications and

Eirini Kapniari1, Prokopios Papadimitriou2, Marianna Dalamaga3

  • 12nd Department of Dermatology and Venereology, National and Kapodistrian University of Athens Medical School, Attikon Hospital, Athens, Greece.

Current Vascular Pharmacology
|May 24, 2020
PubMed

Insights

Psoriasis, a chronic inflammatory skin condition, is linked to cardiovascular disease. Treatments targeting psoriasis inflammation may also benefit cardiovascular health.

Area of Science:

  • Dermatology and Immunology
  • Cardiology
  • Systemic Inflammation

Background:

  • Psoriasis is a chronic inflammatory disease with characteristic skin plaques.
  • It is increasingly recognized as a systemic condition associated with comorbidities like metabolic syndrome, depression, anxiety, and cardiovascular disease.
  • Psoriasis is hypothesized to be an independent cardiovascular risk factor, promoting atherosclerosis through inflammation.

Purpose of the Study:

  • To review current evidence on the relationship between psoriasis and cardiovascular comorbidities.
  • To discuss the underlying mechanisms connecting psoriasis and cardiovascular disease.
  • To investigate the implications for managing psoriasis and its associated cardiovascular risks.

Main Methods:

  • Literature review of existing studies and evidence.
  • Analysis of the association between psoriasis and cardiovascular comorbidities.
  • Examination of proposed pathomechanisms linking psoriasis and cardiovascular disease.

Main Results:

  • Growing evidence supports psoriasis as an independent cardiovascular risk factor.
  • Systemic therapies and biologic agents for psoriasis may impact cardiovascular disease progression.
  • Understanding the interplay between psoriasis and cardiovascular health is crucial for treatment strategies.

Conclusions:

  • Psoriasis is a systemic inflammatory disease with significant cardiovascular implications.
  • Targeting systemic inflammation in psoriasis may offer cardiovascular benefits.
  • Integrated management of psoriasis and cardiovascular risk factors is essential.

Keywords:
Psoriasisanti-inflammatory agentsbiologicscardiovascular diseasesinflammationskin disease

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