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Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
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Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
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Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
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Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
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Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
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Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

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Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
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Preparation of Mycobacterium Tuberculosis Culture Filtrate to Understand TB Pathogenesis
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Serum Procalcitonin Levels Predict Mortality Risk in Patients With Pulmonary Tuberculosis: A Single-Center

Takeshi Osawa1, Masato Watanabe2, Kozo Morimoto1,3

  • 1Department of Respiratory Medicine, Japan Anti-Tuberculosis Association, Fukujuji Hospital, Tokyo, Japan.

The Journal of Infectious Diseases
|May 24, 2020
PubMed
Summary

Serum procalcitonin (PCT) levels can predict mortality risk in patients with pulmonary tuberculosis. Higher PCT levels indicate a greater risk of death, aiding in early identification of high-risk individuals.

Keywords:
biomarkerprocalcitoninprognostic markertuberculosis

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Area of Science:

  • Biochemistry
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Tuberculosis remains a leading global infectious cause of death.
  • Identifying biomarkers for high mortality risk is crucial for improving treatment outcomes.

Purpose of the Study:

  • To investigate serum procalcitonin (PCT) levels as a potential mortality risk indicator in pulmonary tuberculosis patients.
  • To assess the association between PCT levels and mortality risk during antituberculosis treatment.

Main Methods:

  • Prospective enrollment of 252 HIV-negative pulmonary tuberculosis patients initiating treatment.
  • Measurement of serum PCT levels at multiple time points (day 0, 7, 14, 28).
  • Statistical analysis to determine the predictive value of PCT for mortality.

Main Results:

  • Elevated serum PCT levels at all measured time points significantly predicted nonsurvivors.
  • Specific PCT thresholds (e.g., >0.13 ng/mL on day 0) were associated with increased odds ratios for mortality.
  • PCT levels showed weak association with sputum bacterial load and were independent of radiographic findings.

Conclusions:

  • Serum procalcitonin is a promising and independent mortality risk indicator for pulmonary tuberculosis.
  • PCT measurements can aid in identifying patients at higher risk of death.
  • This biomarker may help optimize treatment strategies and improve patient outcomes.