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Cytokines of the IL-17 family in psoriasis
Felix Lauffer1, Kilian Eyerich1, Wolf-Henning Boehncke2
1Department of Dermatology and Allergy Biederstein, University hospital of the Technical University Munich (TUM), Munich, Germany.
Abstract:
Various immune cells and their messenger substances influence the development of psoriasis. Cytokines of the IL-17 family are of particular importance. In addition to IL-17A, which plays a central role in the pathogenesis of psoriasis, other subtypes of the IL-17 family also have a proinflammatory effect. This review provides an up-to-date overview of the immunopathogenesis of psoriasis with regard to the six IL-17 subtypes, in particular their physiological and pathogenic properties, as well as their significance for psoriasis therapy.