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Hyperthermia depletes Oct4 in mouse blastocysts and stem cells

Mo-Bin Cheng1, Xue Wang2, Yue Huang3

  • 1State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, 5 Dongdan Santiao, Beijing, 100005, China.

Stem Cell Research & Therapy
|May 26, 2020
PubMed
Summary

High temperatures reduce Oct4 levels in embryonic stem cells via a specific protein degradation pathway. This finding suggests hyperthermia, like fever, may harm early mammalian embryo development.

Keywords:
BlastocystEmbryonic stem cellsHyperthermiaOct4Pin1

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