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Updated: Dec 20, 2025
08:57
Myosin-Specific Adaptations of In vitro Fluorescence Microscopy-Based Motility Assays
Published on: February 4, 2021
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Myosin X.
1Department of Physiology & Biophysics, Boston University School of Medicine, Boston, MA, USA. tokuo@bu.edu.
Advances in Experimental Medicine and Biology
|May 27, 2020
Summary
Myosin X (Myo10) is an actin motor protein crucial for cell migration and filopodia formation. Myo10 knockout mice have advanced understanding of its in vivo functions, including roles in cancer.
Area of Science:
- Cell Biology
- Molecular Motor Proteins
- Cancer Biology
Background:
- Myosin X (Myo10) is an actin-based motor protein.
- It is known to induce filopodia formation and control cell migration in vitro.
- Myo10 has diverse roles across various cell types and biological processes.
Purpose of the Study:
- To provide a comprehensive overview of Myosin X (Myo10).
- To discuss the structure, regulation, and function of Myo10.
- To explore the role of Myo10 in vivo and in cancer.
Main Methods:
- Review of existing literature on Myosin X (Myo10).
- Analysis of data from Myo10-knockout (Myo10KO) mice.
- Examination of Myo10's gene and protein structure, including its domains (PH, MyTH4, FERM).
Main Results:
- Myo10 plays significant roles in cell migration, filopodia formation, and various cellular processes.
- Myo10-knockout mice have enabled in-depth in vivo studies.
- Myo10 is implicated in cancer cell invasion and metastasis.
Conclusions:
- Myosin X (Myo10) is a multifunctional protein with critical roles in cell biology.
- Further research, particularly using Myo10KO models, is essential for understanding its complex functions.
- Myo10 represents a potential therapeutic target in cancer.
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