[Catabolyte inhibition of lactate transport in Escherichia coli]

E. coli cells growing on the medium containing glucose and lactate do not utilize lactate. One reason of preferential utilization of glucose is catabolite inhibition of lactate transport. It is necessary for glucose to penetrate into the cell to inhibit lactate transport. Besides glucose the inhibition of the lactate transport is also caused by fructose and by non-metabolized analogue of glucose--alpha-methylglucoside.