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[Ferrokinetic studies with Fe-59 in idiopathic hemochromatosis and other forms of iron overload]

U Schmidt1, L Senf, E Preu

  • 1Klinik für Innere Medizin, Medizinischen Akademie Erfurt.

Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete
|December 1, 1988
PubMed

Conventional ferrokinetic studies were done in patients with idiopathic hemochromatosis, secondary siderosis of the liver and iron overload in consequence of sideroblastic or aplastic anaemia. By means of the isotope 59Fe we determined the clearance of radioiron from the plasma, the plasma iron turnover, the utilization of iron by the erythropoesis and the iron uptake by the liver. The later value showed a good correlation with the iron content of the liver determined by atomic absorption spectrometry as well in patients with hemochromatosis as in patients with secondary siderosis of the liver. The 59Fe uptake by the liver was normal in treated hemochromatosis. There was no correlation between the degree of the iron overload and the 59Fe uptake by the liver in patients with anaemia.

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