Exposure pathways, levels and toxicity of polybrominated diphenyl ethers in humans: A review

Polybrominated diphenyl ethers (PBDEs) are extensively used as brominated flame retardants (BFRs) in different types of materials, which have been listed as Persistent Organic Pollutants (POPs) by the Stockholm Convention in 2009 and 2017. Due to their ubiquities in the environment and toxicities, PBDEs have posed great threat to both human health and ecosystems. The aim of this review is to offer a comprehensive understanding of the exposure pathways, levels and trends and associated health risks of PBDEs in human body in a global scale. We systematically reviewed and described the scientific data of PBDE researches worldwide from 2010 to March 2020, focusing on the following three areas: (1) sources and human external exposure pathways of PBDEs; (2) PBDE levels and trends in humans; (3) human data of PBDEs toxicity. Dietary intake and dust ingestion are dominant human exposure pathways. PBDEs were widely detected in human samples, especially in human serum and human milk. Data showed that PBDEs are generally declining in human samples worldwide as a result of their phasing out. Due to the common use of PBDEs, their levels in humans from the USA were generally higher than that in other countries. High concentrations of PBDEs have been detected in humans from PBDE production regions and e-waste recycling sites. BDE-47, -153 and -99 were proved to be the primary congeners in humans. Human toxicity data demonstrated that PBDEs have extensively endocrine disruption effects, developmental effects, and carcinogenic effects among different populations.