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Galectin-3: Roles in Neurodevelopment, Neuroinflammation, and Behavior
Ivan Srejovic1, Dragica Selakovic1, Nemanja Jovicic2
1Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia.
Biomolecules
|May 28, 2020
Summary
Galectin-3 is crucial in the nervous system, impacting brain development and glial cells. This protein plays a role in neurodegenerative diseases but also shows protective effects, suggesting it
Area of Science:
- Neuroscience
- Cell Biology
- Immunology
Background:
- Galectin-3 is implicated in mammalian cell functions and various diseases.
- Its specific roles in the nervous system are increasingly recognized.
Purpose of the Study:
- To review recent findings on Galectin-3's functions in the nervous system.
- To explore its involvement in brain development, glial cells, and neuroinflammation.
Main Methods:
- Literature review of published research, including the authors' own data.
- Analysis of Galectin-3's roles in neurodevelopment and glial cell interactions.
Main Results:
- Galectin-3 influences brain development and glial cell activity.
- It is involved in neuroinflammatory and neurodegenerative conditions like Alzheimer's and Parkinson's diseases.
- Evidence suggests both pathogenic and protective (anti-apoptotic) roles.
Conclusions:
- Galectin-3 is a key player in central nervous system disorders.
- Its modulation may offer therapeutic potential for neurodegenerative diseases.
