Related Experiment Video

Updated: Dec 20, 2025

Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability
08:22

Remotely Supervised Transcranial Direct Current Stimulation: An Update on Safety and Tolerability

Published on: October 7, 2017

8.4K

Effectiveness and Safety of a Clonidine Adhesive Patch for Children With Tic Disorders: Study in a Real-World

Chunsong Yang1,2, BingYao Kang3, Dan Yu4

  • 1Department of Pharmacy, Evidence-Based Pharmacy Center, West China Second Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China.

Frontiers in Neurology
|May 28, 2020
PubMed

Insights

The clonidine adhesive patch (CAP) shows effectiveness and safety for managing tic disorders (TD) in children within a real-world setting. Further large-scale, long-term studies are recommended to confirm these findings.

Area of Science:

  • Pediatric Neurology
  • Pharmacology
  • Real-World Evidence

Background:

  • Real-world evidence (RWE) complements randomized controlled trials by offering insights from observational studies and registries.
  • This study investigated the effectiveness and safety of the clonidine adhesive patch (CAP) for treating tic disorders (TD) in a real-world setting (RWS).
  • Tic disorders affect children and can impact quality of life, necessitating effective treatment options.

Purpose of the Study:

  • To evaluate the real-world effectiveness of the clonidine adhesive patch (CAP) in children with tic disorders (TD).
  • To assess the safety profile of the CAP in pediatric patients within a real-world clinical environment.
  • To compare CAP treatment with other pharmacologic interventions for TD in a Chinese pediatric neurology clinic.

Main Methods:

  • An open-label, non-interventional, post-marketing observational study was conducted in a real-world setting.
  • 150 children diagnosed with TD were enrolled and treated with either tiapride, CAP, or a combination of CAP and tiapride for 6 weeks.
  • Tic symptom severity was assessed using the Yale Global Tic Severity Scale (YGTSS) at baseline and at weeks 4, 8, and 12.

Main Results:

  • The mean YGTSS scores improved from baseline across all treatment groups (tiapride, CAP, CAP + tiapride).
  • No statistically significant differences in YGTSS score reduction were observed between the different pharmacologic interventions.
  • No serious adverse events were reported, and the prevalence of adverse events did not significantly differ between the groups.

Conclusions:

  • The clonidine adhesive patch (CAP) demonstrates effectiveness and a favorable safety profile for managing tic disorders in a real-world setting.
  • The study suggests CAP is a viable treatment option for pediatric TD, comparable to other interventions.
  • Larger sample sizes and longer follow-up periods are needed to further validate these findings and explore long-term outcomes.

Keywords:
clonidine adhesive patcheffectivenessreal-world studysafetytic disorders

More Related Videos

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients05:48

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients

Published on: June 12, 2020

6.2K
Non-Invasive Modulation and Robotic Mapping of Motor Cortex in the Developing Brain08:26

Non-Invasive Modulation and Robotic Mapping of Motor Cortex in the Developing Brain

Published on: July 1, 2019

7.0K

Related Concept Videos

Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
197
Patch Clamp01:18

Patch Clamp

Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...
6.1K
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
646
Cholinergic Antagonists: Pharmacokinetics01:24

Cholinergic Antagonists: Pharmacokinetics

Cholinergic antagonists—such as antimuscarinics—are available in oral, topical, ocular, parenteral, and inhalational formulations. Most antimuscarinics are oral formulations,  while scopolamine is available as a topical patch, and ipratropium and tiotropium are available as inhalation aerosols or powders. Atropine, tropicamide, and cyclopentolate are topically instilled in the eye. Most antimuscarinics are lipid-soluble and readily absorbed from the gastrointestinal tract and...
839
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
662
Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers01:24

Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers

Adrenergic stimulation generally impacts cardiac rate and rhythm. Specifically, stimulation of the β-adrenoceptors triggers an increase in intracellular calcium ion influx and pacemaker currents, which may cause arrhythmias. Catecholamines like adrenaline also demonstrate β2-adrenoceptor-mediated hypokalemia, impacting cardiac action potential and disrupting the normal cardiac rhythm. Class II antiarrhythmic drugs are β-adrenoceptor antagonists or β-blockers, which...
1.3K