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Bipolar Disorder

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.

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Resting-State Network Patterns Underlying Cognitive Function in Bipolar Disorder: A Graph Theoretical Analysis.

Genevieve McPhilemy¹, Leila Nabulsi¹, Liam Kilmartin²

¹Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine, Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.

Brain Connectivity

|May 28, 2020

Summary

This summary is machine-generated.

Altered brain connectivity patterns in bipolar disorder (BD) affect response timing, with distinct patterns observed compared to controls. Inhibitory neural activity at rest is linked to improved memory performance across all participants.

Keywords:

bipolar disorder cognition graph theory network analysis resting state

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Microstate and Omega Complexity Analyses of the Resting-state Electroencephalography

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Area of Science:

Neuroscience
Cognitive Science
Psychiatry

Background:

Resting-state neural activity patterns are crucial for cognitive function.
Bipolar disorder (BD) is associated with widespread cognitive impairments.
Altered brain connectivity may underlie cognitive deficits in BD.

Purpose of the Study:

To investigate network-based functional connectivity in bipolar disorder (BD) compared to healthy controls.
To examine relationships between resting-state brain networks and cognitive performance across multiple domains.
To identify specific connectivity alterations associated with cognitive deficits in BD.

Main Methods:

Constructed resting-state functional networks using correlation matrices of regional brain activity.
Assessed cognitive performance using standardized tests (WAIS, CANTAB, Reading the Mind in the Eyes).
Employed permutation-based statistics to analyze network-cognition relationships.

Main Results:

Faster response times in controls correlated with synchronous activity; in BD, antisynchronous activity was related.
Antisynchronous activity across multiple brain regions correlated with enhanced memory performance in all participants.
No significant relationships were found between resting-state subnetworks and intelligence, executive function, or social cognition.

Conclusions:

Bipolar disorder exhibits altered intrinsic connectivity patterns affecting response timing.
Resting-state inhibitory influences within functional networks facilitate memory processing.
Network-based analysis reveals distinct connectivity profiles underlying cognitive function in BD.