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Updated: Dec 20, 2025

Assessment of Open Probability of the Mitochondrial Permeability Transition Pore in the Setting of Coenzyme Q Excess
Published on: June 1, 2022
ATP synthase c-subunit ring as the channel of mitochondrial permeability transition: Regulator of metabolism in
Nelli Mnatsakanyan1, Elizabeth Ann Jonas1
1Section of Endocrinology, Department of Internal Medicine, Yale University, New Haven, CT, USA.
Abstract:
The mitochondrial permeability transition pore (mPTP) or mitochondrial megachannel is arguably one of the most mysterious phenomena in biology today. mPTP has been at the center of ongoing extensive scientific research for the last several decades. In this review we will discuss recent advances in the field that enhance our understanding of the molecular composition of mPTP, its regulatory mechanisms and its pathophysiological role. We will describe our recent findings on the role of ATP synthase c-subunit ring as a central player in mitochondrial permeability transition and as an important metabolic regulator during development and in degenerative diseases.
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