Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Autoimmune Disorders

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Gephyrin Neurological Autoimmunity.

Annals of neurology·2026

Same author

Septin multimer autoantibodies in severe motor neuropathy mimicking lower motor neuron disease.

Brain : a journal of neurology·2026

Same author

AEGIS reveals epitope- and clone-resolved convergence of CNS B and T cell autoreactivity in ROHHAD.

bioRxiv : the preprint server for biology·2026

Same author

Long-Term Outcomes in Stiff Person Spectrum Disorder.

European journal of neurology·2026

Same author

Novel methods for neural IgG characterization and validation in autoimmune neurologic disorders.

Journal of immunological methods·2026

Same author

GAD65 Antibody ELISA With Extended Reportable Range: Validation and Guidance for Neurological Practice.

Annals of clinical and translational neurology·2026

Search research articles

Related Experiment Video

Updated: Dec 20, 2025

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

Published on: December 1, 2023

Contactin-1 autoimmunity: Serologic, neurologic, and pathologic correlates.

Divyanshu Dubey¹, Josephe A Honorat², Shahar Shelly²

¹From the Department of Laboratory Medicine and Pathology, Neurology and Immunology (D.D., J.A.H., S.S., C.J.K., J.R.M., V.A.L., S.J.P., A.M.); Department of Neurology (D.D., J.A.H., S.S., C.J.K., J.R.M., V.A.L., S.J.P., A.M.), Mayo Clinic, Rochester, MN; and Euroimmun (L.K., S.B., C.P.), Lubeck, Germany. dubey.divyanshu@mayo.edu.

Neurology(R) Neuroimmunology & Neuroinflammation

|May 29, 2020

Summary

Contactin-1 IgG autoimmunity often presents as sensory predominant neuropathy with pain and demyelination. Consider paraneoplastic causes and targeted immunotherapy for this rare condition.

More Related Videos

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis

Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis

Published on: September 26, 2012

Related Experiment Videos

Last Updated: Dec 20, 2025

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research

Published on: December 1, 2023

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis

Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis

Published on: September 26, 2012

Area of Science:

Neurology
Immunology
Neuroimmunology

Background:

Autoimmune neuropathies are a diverse group of disorders.
Contactin-1 is a cell adhesion molecule implicated in nervous system function.
Understanding specific autoantibodies aids in diagnosis and treatment.

Purpose of the Study:

To characterize contactin-1 autoimmunity.
To determine its frequency, clinical phenotype, and associated features.
To guide diagnostic and therapeutic strategies.

Main Methods:

Reevaluation of archived sera for contactin-1 immunoglobulin (Ig) G.
Confirmation of antibody specificity using recombinant protein assays.
Screening of patients with chronic/relapsing demyelinating neuropathies.

Main Results:

Identified 10 contactin-1 IgG seropositive cases (2% of tested neuropathies).
Common features included sensory predominant presentation (90%), neuropathic pain (60%), and subacute progression (50%).
Demyelinating changes on electrophysiology, elevated CSF protein, and nerve root enhancement were noted; 3 cases had paraneoplastic associations.

Conclusions:

Contactin-1 IgG autoimmunity presents with distinct sensory and pain features and demyelination.
Paraneoplastic etiology should be considered in relevant cases.
Testing for contactin-1 IgG can inform immunotherapy selection, particularly for second-line treatments.