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Updated: Dec 20, 2025

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
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Prothrombin Gene G20210A Variant in Angiographically Documented Patients with Coronary Artery Stenosis

Leyla Pourgholi1, Hamidreza Goodarzynejad2, Shayan Ziaee1

  • 1Department of Molecular Pathology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

The Journal of Tehran Heart Center
|May 29, 2020
PubMed

Insights

The prothrombin G20210A variant was not found to be a significant risk factor for coronary artery disease (CAD) or its severity in this study. Further research is needed to clarify the role of this genetic variant in cardiovascular health.

Area of Science:

  • Cardiovascular Genetics
  • Thrombosis Research

Background:

  • Inconclusive evidence links the prothrombin G20210A variant to coronary artery disease (CAD) risk.
  • The role of this genetic variant in CAD development and progression requires further investigation.

Purpose of the Study:

  • To investigate the association between the prothrombin G20210A variant and the presence and severity of CAD.
  • To determine if the G20210A variant influences CAD risk or its clinical manifestation.

Main Methods:

  • 1460 patients undergoing elective coronary angiography were enrolled.
  • Coronary angiography assessed CAD presence and severity using Gensini and vessel scores.
  • Prothrombin G20210A genotypes were determined using PCR-RFLP.

Main Results:

  • No statistically significant difference in Gensini scores between wild-type (GG) and mutant (AA+GA) genotypes (P=0.440).
  • No significant linear trend observed for the number of diseased vessels (vessel score) in relation to genotype (P=0.765).

Conclusions:

  • The study did not confirm the prothrombin G20210A variant as a significant determinant of CAD risk.
  • The G20210A variant does not appear to influence the severity of coronary artery disease in this patient cohort.

Keywords:
Coronary angiographyCoronary artery diseaseProthrombinSingle-nucleotide polymorphism

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