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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Domino ring opening and selective O/S-alkylation of cyclic ethers and thioethers
Manickam Bakthadoss1, Vishal Agarwal2, Thirupathi Reddy Tadiparthi2
1Department of Chemistry, Pondicherry University, Pondicherry, 605 014, India. bhakthadoss@yahoo.com.
Abstract:
Chemoselective domino ring opening and selective O/S-alkylation of ethers/thioethers over enol C/O alkylation has been observed. Various 2-aryl chromanones/thiochromanones with alkyl/allyl bromides were smoothly converted into the corresponding highly functionalized ethers and thioethers in excellent yields with high selectivity. An unusual, chemoselective domino ring opening and selective ether/thioether O/S-alkylation over. An unusual, chemoselective domino ring opening and selective ether/thioether O/S alkylation over enol C/O alkylation has been observed.
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