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Engineering mesenchymal stem cells: a novel therapeutic approach in breast cancer
Razieh Heidari1, Neda Gholamian Dehkordi2, Roohollah Mohseni3
1Department of Medical Biotechnology, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Abstract:
Breast cancer is one of the most prevalent and deadliest cancers among women in the world because of its aggressive behaviour and inadequate response to conventional therapies. Cellular and gene therapies based on mesenchymal stem cells (MSCs) represent promising treatment strategies for multiple diseases, such as cancers. MSCs are multipotent adult stem cells with important features for cell therapy, such as tissue homing to injured sites, their differentiation potential, their capacity of secreting plenty of trophic factors, and low immunogenicity. The quite easy isolation of these cells from various types of tissues are associated with no ethical concern when dealing with foetal or embryonic stem cells. The MSCs exhibit both pro and anti-oncogenic properties. However, genetic engineering of MSCs and nanoparticles is being employed as a means to solve some of these problems and improve the antitumor properties of these cells. The tumour-homing ability of MSCs and their exosomes to tumour niches have made them as a promising vector for targeted delivery of therapeutic agents to tumours site. The present study investigated MSCs specifications, pro- and anti-oncogenic properties of MSCs in breast cancer, and reviewed targeted breast cancer therapy via engineered MSCs, likely as potent cellular vehicles.
Insights
Mesenchymal stem cells (MSCs) show potential for breast cancer therapy due to their tumor-homing ability. Genetic engineering enhances MSCs to improve their anti-tumor properties for targeted drug delivery.
Area of Science:
- Oncology
- Stem Cell Biology
- Biotechnology
Background:
- Breast cancer remains a leading cause of death in women globally, often resisting conventional treatments.
- Mesenchymal stem cells (MSCs) offer therapeutic potential due to their unique properties like tissue homing and low immunogenicity.
- MSCs possess both tumor-promoting and tumor-inhibiting characteristics, necessitating further research for optimized cancer therapy.
Purpose of the Study:
- To investigate mesenchymal stem cells (MSCs) and their dual role in breast cancer.
- To review the application of engineered MSCs for targeted breast cancer therapy.
- To explore MSCs and their exosomes as potential vectors for drug delivery in breast cancer treatment.
Main Methods:
- Review of scientific literature on mesenchymal stem cells (MSCs) and breast cancer.
- Analysis of MSCs' tumor-homing capabilities and therapeutic potential.
- Examination of genetic engineering strategies to enhance MSC anti-tumor properties.
Main Results:
- MSCs exhibit tumor-homing properties, making them suitable for targeted delivery systems.
- Genetic engineering and nanoparticle integration can enhance the anti-cancer efficacy of MSCs.
- MSCs and their exosomes show promise as cellular vehicles for targeted breast cancer therapy.
Conclusions:
- Engineered mesenchymal stem cells (MSCs) represent a promising strategy for targeted breast cancer treatment.
- Further research into MSCs' pro- and anti-oncogenic roles is crucial for developing effective therapies.
- MSCs offer a viable platform for developing novel drug delivery systems against breast cancer.
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