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Correlation between immune response and self-reported depression during convalescence from COVID-19
Bo Yuan1, Weixin Li2, Hanqing Liu3
1Department of Neurology, Shenzhen Samii Medical Center, Shenzhen 518118, China.
Brain, Behavior, and Immunity
|May 29, 2020
Summary
Depression in COVID-19 survivors may be linked to an increased immune response, with higher white blood cell and neutrophil counts observed. Further research is needed to understand this connection and guide patient care.
Area of Science:
- Immunology
- Psychiatry
- Infectious Diseases
Background:
- Self-reported depression is noted in COVID-19 patients post-discharge.
- The underlying causes of depression during the COVID-19 convalescent period are not well understood.
Purpose of the Study:
- To investigate the mental health status of convalescent COVID-19 patients.
- To explore potential links between self-reported depression and clinical characteristics, including immune markers.
Main Methods:
- A retrospective analysis of 96 convalescent COVID-19 patients surveyed via an online questionnaire.
- Evaluation of clinical characteristics, including routine blood and biochemical data.
Main Results:
- Patients reporting depression showed elevated immune responses.
- Increased white blood cell counts, neutrophil counts, and neutrophil-to-lymphocyte ratio were associated with self-reported depression.
Conclusions:
- Self-reported depression appears early in COVID-19 convalescence.
- Apparent changes in immune function warrant emphasis in patient follow-up.
- Psychological interventions are recommended for convalescent COVID-19 patients.
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