Outcomes of freehand interstitial brachytherapy in advanced gynecologic malignancies

The purpose of the study is to present the first results of freehand interstitial brachytherapy (ISBT) used to treat patients with carcinoma of the cervix and the vagina.

Patients diagnosed with carcinoma of the cervix or carcinoma of the vagina who were not suitable for intracavitary brachytherapy were treated with freehand ISBT. The implant was performed transperineally using C arm or transrectal ultrasound guidance. Patients received an external beam radiotherapy dose of 50 Gy in 25 fractions. The dose delivered by high-dose-rate ISBT was 18 Gy in three fractions, 6 Gy per fraction, 6 h apart. The brachytherapy dose volume parameters were analyzed after CT-based planning using GEC ESTRO image-guided brachytherapy-based guidelines.

From June 2018 till November 2018, 14 patients were treated with freehand ISBT. The mean dose received by 90% of the high-risk clinical target volume (D₉₀) was 82 Gy EQD2₁₀ for patients with carcinoma of the cervix and 80 Gy EQD2₁₀ for patients with carcinoma of the vagina_. The mean dose received by 2 cc volume of the bladder and rectum was 80 Gy EQD2₃ and 70 Gy EQD2₃ for patients with carcinoma of the cervix and 75 Gy EQD2₃ and 72 Gy EQD2₃ for patients with carcinoma of the vagina, respectively. The mean dose received by 2 cc of the sigmoid was 65 Gy EQD2₃ for cervical carcinoma and 58 Gy EQD2₃ for vaginal carcinoma, respectively. At a median followup of 14 months, 2 patients developed local recurrence. Two patients developed Grade 2 gastro intestinal toxicity, and 1 patient developed Grade 2 genitourinary toxicity. None of the patients developed Grade 3 or 4 toxicities.

A freehand interstitial implant is feasible in resource limited settings and provides acceptable local control with minimal acute toxicity.