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Mutagenicity and Carcinogenicity

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...

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Updated: Dec 20, 2025

A Strategy to Identify Compounds that Affect Cell Growth and Survival in Cultured Mammalian Cells at Low-to-Moderate Throughput

A Strategy to Identify Compounds that Affect Cell Growth and Survival in Cultured Mammalian Cells at Low-to-Moderate Throughput

Published on: September 22, 2019

Assessing Toxicity with Human Cell-Based In Vitro Methods.

Daniele Zink¹, Jacqueline Kai Chin Chuah², Jackie Y Ying³

¹NanoBio Lab, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, The Nanos, #09-01, Singapore 138669, Singapore; Innovations in Food and Chemical Safety Programme, A*STAR, Singapore.

Trends in Molecular Medicine

|May 30, 2020

Summary

This summary is machine-generated.

The field of toxicology is shifting towards non-animal testing methods, utilizing advanced cell-based assays and computational models for human health risk assessment. These innovative approaches accelerate compound evaluation and promise continued advancements in safety testing.

Keywords:

hazard identification high-throughput screening human cell model in vitro toxicology organotypic model pluripotent stem cell

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Last Updated: Dec 20, 2025

A Strategy to Identify Compounds that Affect Cell Growth and Survival in Cultured Mammalian Cells at Low-to-Moderate Throughput

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Published on: September 22, 2019

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Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

Published on: June 17, 2015

Area of Science:

Toxicology and Pharmacology
Biotechnology
Computational Biology

Background:

Growing demand for non-animal testing methods in toxicology.
Need for high-throughput screening of numerous chemical compounds.
Limitations of traditional animal testing models.

Purpose of the Study:

To review the progress and innovative technologies in alternative methods for toxicity assessment.
To highlight the integration of in vitro, in silico, and bioinformatics approaches.
To discuss the future outlook of predictive toxicology.

Main Methods:

Development and application of cell-based in vitro methods.
Utilizing induced pluripotent stem cells, organoids, and organotypic cocultures.
Implementation of microfluidic 'multiorgan' chips.
Integration of bioinformatics and in silico modeling.

Main Results:

Significant advancements in developing and applying novel in vitro methods.
Emergence of innovative technologies like organoids and 'multiorgan' chips.
Successful combination of in vitro data with computational approaches for enhanced assessment.

Conclusions:

Alternative methods are crucial for replacing animal experiments in toxicology.
Innovative technologies are revolutionizing the assessment of adverse health effects.
The synergy between in vitro and in silico methods offers powerful tools for future toxicity testing.