Neural correlates and network dynamics of uncommon semiologies in the cingulo-insulo-opercular network explored with
Ayman A AbdelHamid1, Mohammed AlShammri2, Mohammad Alkouli1
1Department of Bioengineering and Nanomedicine, Research and Innovation, King Faisal Specialist Hospital & Research Centre, P.O. Box 3354, Riyadh 11211, Saudi Arabia.
This study reveals that uncommon epilepsy symptoms like smiling and laughter involve distinct brain network patterns. These findings aid in interpreting stereo-electroencephalography (SEEG) data for epilepsy surgery.
Area of Science:
- Neuroscience
- Epileptology
- Systems Neuroscience
Background:
- The cingulo-insulo-opercular network is implicated in various neurological functions.
- Uncommon semiologies during epilepsy seizures may provide insights into network involvement.
- Stereo-electroencephalography (SEEG) is crucial for detailed localization of seizure origins.
Purpose of the Study:
- To investigate five uncommon semiologies (smiling, laughter, neck choreoathetosis, face wiping, arm-over-head pose) potentially linked to cingulo-insulo-opercular network activity.
- To characterize the specific cortical network signatures associated with each semiology using SEEG.
- To explore the utility of these findings for epilepsy diagnosis and presurgical planning.
Main Methods:
- Analysis of SEEG data from 11 patients exhibiting target semiologies among 75 reviewed cases.
- Utilized video-annotated epochs, MATLAB-based pipeline with band-specific filtering, and event-related desynchronization/synchronization (ERDS) analysis.
- Employed quantitative ERDS, anatomical localization, regional clustering, and statistical corrections to define semiology-associated networks.
Main Results:
- All five semiologies converged on a shared cingulate-insula-centered network, involving frontal opercular, orbitofrontal, and lateral prefrontal regions.
- Distinct frequency-dependent network patterns were observed: face wiping showed theta/delta synchronization/desynchronization; laughter and smiling involved overlapping but differentially weighted networks; neck choreoathetosis and arm-over-head pose displayed delta-dominant patterns.
- Network membership remained stable across varying channel selection thresholds.
Conclusions:
- Uncommon ictal and postictal semiologies are associated with distinct, yet overlapping, frequency-dependent cortical network signatures within the cingulo-insulo-opercular system.
- These findings enhance the interpretation of SEEG data for network-based localization.
- The study supports presurgical hypothesis generation in patients with suspected cingulo-insulo-opercular epilepsy.
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