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Low prevalence and disease severity of COVID-19 in post-liver transplant recipients-A single centre experience

Anita Verma1, Shirin Elizabeth Khorsandi1, Annalisa Dolcet1

  • 1Institute of Liver Studies, King's College Hospital, London, UK.

Liver International : Official Journal of the International Association for the Study of the Liver
|May 30, 2020
PubMed

Insights

Liver transplant recipients show a low incidence of COVID-19 with less severe symptoms than expected. This may be due to adherence to self-isolation and optimal immunosuppression levels modulating the immune response.

Area of Science:

  • Hepatology
  • Transplant Surgery
  • Infectious Diseases

Background:

  • Coronavirus disease 2019 (COVID-19) poses a significant risk to immunosuppressed individuals.
  • Liver transplant recipients represent a vulnerable population during the COVID-19 pandemic.
  • Understanding COVID-19's impact on this cohort is crucial for patient management.

Purpose of the Study:

  • To report on the incidence and severity of COVID-19 in liver transplant recipients.
  • To compare outcomes in liver transplant recipients with the general population and other solid organ recipients.
  • To explore potential factors influencing COVID-19 outcomes in this group.

Main Methods:

  • Retrospective analysis of COVID-19 cases in liver transplant recipients (n=5).
  • Data collected from a high-volume UK liver transplant unit.
  • Comparison with a larger follow-up cohort (n=4500) and general population data.

Main Results:

  • A low incidence of COVID-19 was observed among liver transplant recipients.
  • Symptoms appeared less severe than anticipated when compared to other groups.
  • No specific details on symptom severity or outcomes were provided for the 5 cases.

Conclusions:

  • Liver transplant recipients may experience a lower incidence and severity of COVID-19.
  • Potential protective factors include strict adherence to self-isolation and an 'ideal' level of immunosuppression.
  • Further research with larger cohorts is needed to confirm these preliminary findings.

Keywords:
COVID-19immunosuppressionliver transplant

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