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Matrix metalloproteinases (MMPs) family gene polymorphisms and the risk of multiple sclerosis: systematic review and

Mina Mohammadhosayni1, Arezou Khosrojerdi2, Keivan Lorian3

  • 1Department of Immunology, Faculty of Medicine, Shahed University, Tehran, Iran.

BMC Neurology
|May 31, 2020
PubMed
Abstract

Insights

This meta-analysis found a significant association between the MMP-9 -1562 C/T polymorphism and Multiple Sclerosis (MS) risk. The MMP-9 polymorphism increases the likelihood of developing MS.

Area of Science:

  • Genetics
  • Neuroimmunology
  • Molecular Biology

Background:

  • Polymorphisms in Matrix metalloproteinases (MMPs) genes have been linked to Multiple Sclerosis (MS) risk.
  • Previous studies reported inconsistent and inconclusive findings.
  • This study addresses the need for a comprehensive analysis of specific MMP gene polymorphisms and MS susceptibility.

Purpose of the Study:

  • To systematically review and meta-analyze the association between MMP-9 (-1562 C/T), MMP-3 (-1612 5A/6A), and MMP-2 (-1306 C/T) polymorphisms and MS susceptibility.
  • To clarify the role of these MMP gene variations in the risk of developing Multiple Sclerosis.
  • To provide a statistically robust assessment of the evidence linking these polymorphisms to MS.

Main Methods:

  • A systematic search of major electronic databases (Scopus, PubMed) was conducted for studies published before December 2019.
  • Included studies investigated the association between MMP-9 (-1562 C/T), MMP-3 (-1612 5A/6A), and MMP-2 (-1306 C/T) polymorphisms and MS susceptibility.
  • Odds ratios (OR) and 95% confidence intervals (CI) were calculated to determine the level of association in a pooled analysis.

Main Results:

  • The meta-analysis included 15 studies with 2430 MS cases and 2304 controls.
  • A statistically significant association was found for the MMP-9 -1562 C/T polymorphism across all five tested models (dominant, recessive, allelic, TT vs. CC, CT vs. CC).
  • Specific results showed increased MS risk with ORs ranging from 1.51 to 3.20 (P < 0.05 for all comparisons).

Conclusions:

  • The meta-analysis confirms a significant association between the MMP-9 -1562 C/T Single-Nucleotide Polymorphism (SNP) and Multiple Sclerosis susceptibility.
  • This specific MMP-9 polymorphism is associated with an increased risk of developing MS.
  • The findings contribute to understanding the genetic factors influencing MS development.
Keywords:
Central nervous systemGenetic polymorphismMatrix metalloproteinasesMeta-analysisMultiple sclerosis

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