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Contrast Media-Different Types of Contrast Media, Their History, Chemical Properties, and Relative Nephrotoxicity
Sadichhya Lohani1, Michael R Rudnick2
1Renal-Electrolyte and Hypertension Division, Penn Presbyterian Medical Center, Perelman School of Medicine, University of Pennsylvania, 51N 39th Market Street, Suite 240, Philadelphia, PA 19104, USA.
Contrast media (CM) have evolved since the 1890s, with newer agents reducing nephrotoxicity. This review examines CM history, properties, and their impact on contrast-induced nephropathy (CIN) and kidney injury.
Area of Science:
- Radiology
- Nephrology
- Pharmacology
Background:
- Contrast media (CM) development began in the 1890s with radiography.
- Nephrotoxicity is a significant limitation of ideal CM.
- High-osmolar CM are no longer used due to higher nephrotoxicity compared to current agents.
Purpose of the Study:
- To review the history and chemical properties of CM.
- To analyze experimental and clinical studies on CM.
- To evaluate the role of CM in contrast-induced nephropathy (CIN).
Main Methods:
- Literature review of historical data on CM.
- Analysis of chemical properties of different CM groups.
- Examination of experimental and clinical studies on CM-induced nephrotoxicity.
Main Results:
- High-osmolar CM have been largely replaced by safer alternatives.
- Contrast-induced nephropathy (CIN) is a common cause of hospital-acquired acute kidney injury.
- CM selection is often based on cost and institutional protocols.
Conclusions:
- Understanding CM evolution is crucial for minimizing kidney injury.
- Further research into CM properties can optimize patient safety.
- Clinical practice guidelines should prioritize nephroprotective strategies when using CM.
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