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Related Experiment Videos

Chemotherapy used in dermatology.

S L Moschella

    Cutis
    |May 1, 1977
    PubMed
    Summary

    Systemic corticosteroids pose risks; cytotoxic and immunosuppressive drugs offer alternatives for dermatologic, immunologic, and proliferative disorders. This guideline details their use, toxicity, and common therapeutic programs.

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    Area of Science:

    • Dermatology
    • Immunology
    • Pharmacology

    Background:

    • Systemic corticosteroids are effective for dermatologic conditions but carry significant long-term risks.
    • Cytotoxic and immunosuppressive drugs are increasingly used for various dermatologic, immunologic, and proliferative disorders.
    • A need exists for guidelines on the safe and effective use of these agents.

    Purpose of the Study:

    • To advocate for and describe a guideline for the use of cytotoxic and immunosuppressive drugs in dermatology.
    • To present the short- and long-term toxicity profiles of these agents.
    • To outline and discuss therapeutic programs for specific conditions.

    Main Methods:

    • Review of current literature and clinical practices regarding cytotoxic and immunosuppressive drug use.
    • Compilation of data on drug efficacy, dosage, and toxicity.
    • Analysis of therapeutic regimens for selected dermatologic conditions.

    Main Results:

    • Guidelines for the use of cytotoxic and immunosuppressive drugs are presented.
    • Detailed information on the toxicity of these agents is provided.
    • Commonly prescribed treatment programs for psoriasis, pemphigus, bullous pemphigoid, cutaneous lymphoma, and metastatic melanoma are discussed.

    Conclusions:

    • Cytotoxic and immunosuppressive drugs represent valuable therapeutic options for various dermatologic conditions.
    • Careful patient selection and monitoring are crucial due to potential toxicities.
    • The provided guideline and treatment outlines aim to optimize the use of these potent medications.

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