Memory improvement in multiple sclerosis after an extensive cognitive rehabilitation program in groups with a...

Area of Science:

• Neuroscience
• Rehabilitation Medicine
• Clinical Psychology

Background:

• Cognitive impairment is a common and disabling symptom in multiple sclerosis (MS).
• Current rehabilitation strategies for MS-related cognitive deficits require further investigation for efficacy.
• Group-based interventions may offer a scalable approach to cognitive rehabilitation.

Purpose of the Study:

• To evaluate the effectiveness of an extended cognitive rehabilitation program delivered in group sessions for individuals with multiple sclerosis.
• To assess the impact of the ProCog-SEP program on verbal memory learning and other cognitive functions.

Main Methods:

• A double-blind, multicenter, randomized trial was conducted.
• Participants (18-60 years, EDSS ≤6.0) with mild to moderate cognitive impairment were randomized to either the ProCog-SEP program or a placebo program.
• ProCog-SEP involved 13 group sessions over 6 months, including psychoeducation and cognitive exercises; the placebo involved non-cognitive activities.

Main Results:

• The ProCog-SEP group showed significant improvements in the learning index (p=0.02) and working memory manipulation (p=0.01).
• Updating capacities also significantly improved in the ProCog-SEP group (p=0.04).
• No significant differences were found in other neuropsychological outcomes or quality of life between the groups.

Conclusions:

• The ProCog-SEP program, consisting of 13 group sessions over 6 months, appears effective in enhancing verbal learning and working memory in people with multiple sclerosis.
• These findings support the use of targeted group cognitive rehabilitation for specific cognitive deficits in MS.