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A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
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Systemic Contact Dermatitis: A review
Francesca Y Baruffi1, Kaushik P Venkatesh1, Kamaria N Nelson2
1The George Washington School of Medicine and Health Sciences, Washington, DC, USA.
Dermatologic Clinics
|June 2, 2020
Summary
Systemic contact dermatitis (SCD) involves hypersensitivity reactions to allergens like plants, foods, metals, and medications. Diagnosis and treatment rely on patch testing and allergen avoidance diets.
Area of Science:
- Immunology
- Dermatology
- Allergy
Background:
- Systemic contact dermatitis (SCD) encompasses diverse syndromes with various triggers.
- SCD is primarily understood as a Type IV hypersensitivity reaction, involving CD8+ T-cells upon reexposure.
- Common allergens include plants, foods, metals, and medications.
Purpose of the Study:
- To elucidate the immunological mechanisms underlying Systemic Contact Dermatitis.
- To outline diagnostic approaches for SCD.
- To detail therapeutic strategies for managing SCD.
Main Methods:
- Review of existing literature on SCD pathogenesis and clinical presentation.
- Analysis of diagnostic methodologies, focusing on epicutaneous patch testing.
- Examination of treatment protocols, emphasizing allergen avoidance.
Main Results:
- SCD is characterized by Type IV (T-cell mediated) and occasionally Type III hypersensitivity.
- Allergens are broadly categorized into plants, foods, metals, and medications.
- Epicutaneous patch testing demonstrates high diagnostic success rates.
Conclusions:
- SCD is an immune-mediated condition triggered by systemic allergen reexposure.
- Accurate diagnosis is achievable through patch testing.
- Allergen avoidance diets are the cornerstone of SCD management.
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